Best Python Build for Season 3 – The First Descendant

by JFFK · September 19, 2025

Welcome to The First Descendant Python Build. This Python Build is updated for Season 3. The Python is a fast firing submachine gun that specializes in reducing the toxic and non-aatribute resistance of enemies.

Table of Contents:

You can also view our All Ultimate Weapons in The First Descendant list.

Python Summary

The Python is an Ultimate Submachine Gun. The Python is a specialized submachine gun invented to strategically utilize toxic Arche.

Name: Python
Type: Submachine Gun
Tier: Ultimate
Unique Ability: Python Instinct

Unique Ability “Python Instinct”

On hitting a Weak Point, inflicts the unique ability Prey on the target enemy.

Prey

Effect	Level 0	Level 1	Level 2	Level 3	Level 4
Duration	1s	1.25s	1.5s	1.75s	2s
Max Stacks	20	22	24	26	28
Non-Attribute Resistance	-2%	-2%	-2%	-2%	-2%
Toxin Resistance	-3.6%	-3.6%	-3.6%	-3.6%	-3.6%
Non-Attribute Resistance per Stack	-1%	-1%	-1%	-1%	-1%
Toxin Resistanc per Stack	-1.3%	-1.3%	-1.3%	-1.3%	-1.3%

Base Weapon Stat Info

Python Build for The First Descendant

Next, let us take a look at an optimized Python Build for The First Descendant. The Python weapon has a very high base fire rate. This weapon also has a high Multi-Hit base value, therefore building more into that makes sense!

Here is all the info you need to build a powerful Python:

Python Modules

Modules are an important part of every weapon build in The First Descendant. For the Python we want to build out its high base Multi-Hit value by adding modules that boost Multi-Hit. Additionally, increasing the magazine size and just generally good mods increase the power tremendously.

General Python Module Configuration Table
Module Slot	Module Name	Socket Type
1	Multi-Percussion Sight	Rutile
2	Multi-Piercing Trigger	Rutile
3	Multi-Piercing Support Ammo	Cerulean
4	Fire Rate Up	Xantic
5	Charge Amplification	Malachite
6	Expand Weapon Charge	Cerulean
7	Action and Reaction	Malachite
8	Rifling Reinforcement	Malachite
9	Toxic Enhancement	Rutile
10	Poison Priority	Rutile

Weapon Readjustment

You can use the Weapon Readjustment at the Weapon Workbench in Albion. Here are the best Weapon Readjustments for the Python:

Multi-Hit Damage
Multi-Hit Chance
Firearm ATK
Rounds per Magazine

In any order. Try to upgrade the Weapon Readjustments to at least purple quality.

Weapon Cores

Weapon Cores juice up your damage quite tremendously. However, especially the later-level Weapon Cores are difficult to get. So start with whatever weapon cores you have available. Weapon Cores drop in the Void Erosion Purge endgame activity.

Higher level Weapon Cores drop in the higher level Void Erosion Purge levels in The First Descendant. However, you can gradually work towards the highest level. I recommend trying to get to level six as soon as possible, since it won’t require to clear many stages and will already increase the power of your weapon tremendously.

Best Weapon Cores for the Python:

Fire Rate (Free Augmentation)
Firearm ATK (Firepower Augmentation)
Fire Rate (Tactical Augmentation)
Sprint Speed or Grapple Hook (Precision Augmentation)
Sprint Speed or Grapple Hook (Precision Augmentation)

Alternatively, you could also go with 1x Fire Rate and 1x Toxic instead of 2x Fire Rate.

Python Lore Info

As the Magisters continued to research Arche, they also attempted to use related technologies to increase the Battle Power of the Descendants. The miniaturized Arche Control System was used in Modules, External Components, and Ultimate Weapons.

Code name “Python” was a piece of equipment invented to be compatible with toxic Arche. When the gun is fired, a small amount of toxic material is sprayed. The minute a bullet penetrates a target’s skin, a neurotoxin is released into their body.

However, because the emission of too much poison when loading the rounds into the weapon’s chamber can have a harmful effect on the user, a series of control procedures made it possible to safely and effectively use the powers of Arche. Thus, only Descendants who possess Arche abilities can use this weapon effectively.